Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents

In this investigation, the synthesis of 2-substituted pyrimidines by the reaction of benzofuranchalcones (3a-d) with urea, thiourea and guanidine hydrochloride was reported. The structuresof title compounds (4a-d), (5a-d) and (6a-d) were established on the basis of analyticaland spectral data. The synthesized compounds were screened for antimicrobial activityand molecular docking studies. Some of the compounds displayed excellent antimicrobialactivity. The molecular docking analysis revealed that compounds 5a and 5c with the lowestbinding energy in comparison to others suggesting its potential as best inhibitor of GluN-6-P.Consequently, it is confirmed from the above analysis that the compounds 5a and 5c mightserve as a useful backbone scaffold for rational design, adaptation and investigation of moreactive analogs as potential broad spectrum antimicrobial agents.